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A Clinical Electrophysiological Study of Emotional Lability in Patients With Systemic Lupus Erythematosus

Received July 27, 2006; revised February 7, 2007; accepted February 12, 2007. All of the authors are affiliated with the Department of Psychiatry at the University of Freiburg; the Department of Developmental Psychiatry at the University of Cambridge; the EEG Department at St. Thomas' Hospital; the Departments of Rheumatology at the Royal Free Hospital, St. Mary's Hospital, St. Thomas' Hospital; the Department of Neuropsychiatry at the Institute of Neurology; and the Human Systems Group at the Defence Science and Technology Laboratory. Address correspondence to Dr. Howard Ring, Developmental Psychiatry Section, Douglas House, 18b Trumpington Rd., Cambridge CB2 8AH, UK; har28{at}cam.ac.uk (e-mail).

Neuropsychiatric symptoms are well recognized in systemic lupus erythematosus (SLE), with depression and anxiety often reported. The authors’ clinical observations suggested emotional lability might also be a noteworthy symptom. In a consecutive series of systemic lupus erythematosus clinic attendees the authors therefore measured depression, anxiety, and emotional lability. Additionally, based on reports linking emotional reactivity and transient mood changes to alterations in early attentional processes, the authors investigated event-related potential indices of preattentive and early orienting responses to auditory stimuli (N1, MMN, P3a and P3b). The authors observed that 15 of 32 participants with systemic lupus erythematosus had high lability scores and, comparing event-related potential measures between the high and low lability subgroups, noted that those with greater emotional lability demonstrated reduced response latencies in N1 and MMN paradigms.

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