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Sex-Dependent Hippocampal Volume Reductions in Schizophrenia Relate to Episodic Memory Deficits

Received October 26, 2006; revised March 16 and April 16, 2007; accepted April 16, 2007. Drs. Exner, Nehrkorn, Martin, and Rief are affiliated with the Department of Clinical Psychology and Psychotherapy at the University of Marburg, Germany; Dr. Nehrkorn is affiliated with the Department of Neurology at the University of Aachen, Germany; Dr. Huber is affiliated with the Department of Psychiatry and Psychotherapy at the University of Marburg, Germany; Dr. Shiratori is affiliated with the Department of Neuroradiology at the University of Marburg, Germany. Address correspondence to Dr. Cornelia Exner, Department of Clinical Psychology and Psychotherapy, University of Marburg, Gutenbergstr. 18, D-35032 Marburg, Germany; exnerc{at}staff.uni-marburg.de (e-mail).

ABSTRACT

Morphological abnormalities of the hippocampus might form the neurobiological basis of memory dysfunction in schizophrenia. Hippocampal volume was found to be bilaterally reduced in male, but not in female, subjects with schizophrenia. Right hippocampal volume was significantly related to impaired visual learning.

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